LXRX Insider Trading

Lexicon Pharmaceuticals, Inc. (LXRX) operates in the Healthcare sector, specifically the Biotechnology industry, with a market capitalization near $715.2M, listed on NASDAQ, employing roughly 81 people, carrying a beta of 1.08 to the broader market. Lexicon Pharmaceuticals, Inc. Led by Michael S. Exton, public since 2000-04-07.

In the last 12 months, Lexicon Pharmaceuticals, Inc. insiders made 8 buy transactions and 0 sale transactions.

DateNameTypeSharesPriceValue
Jun 4, 2026Swain Judith LM-Exempt89,312$0.00$0
Jun 4, 2026Swain Judith LM-Exempt89,312$0.00$0
Jun 4, 2026Sullivan Diane E.M-Exempt89,312$0.00$0
Jun 4, 2026Sullivan Diane E.M-Exempt89,312$0.00$0
Jun 4, 2026SOBECKI CHRISTOPHER JM-Exempt89,312$0.00$0
Jun 4, 2026SOBECKI CHRISTOPHER JM-Exempt89,312$0.00$0
Jun 4, 2026Cheung IvanM-Exempt89,312$0.00$0
Jun 4, 2026Cheung IvanM-Exempt89,312$0.00$0
Jun 4, 2026BARKER SAM LM-Exempt89,312$0.00$0
Jun 4, 2026BARKER SAM LM-Exempt89,312$0.00$0

LXRX Insider Activity by Quarter

Reported Form 4 and Form 5 lines under LXRX's own SEC company ID, by transaction date, back to Q4 2024. Purchases and sales are code P / S (open market or private) in the company's shares; other lines are purchases and sales of other securities (options, warrants, preferred), awards, exercises, tax withholding, gifts and other acquisitions and dispositions. Later filings and amendments can change the current quarter. Earlier quarters are not shown: the filings read reach back to May 2, 2022, and a quarter counts only when every filing for it was read.

QuarterPurchasesBoughtSalesSoldOther Lines
Q4 2026 (so far)0N/A0N/A0
Q3 20260N/A0N/A0
Q2 20260N/A0N/A31
Q1 20268$2.7M0N/A62
Q4 20250N/A0N/A0
Q3 20250N/A0N/A0
Q2 20250N/A0N/A26
Q1 20250N/A0N/A57
Q4 20240N/A0N/A1

LXRX Institutional Ownership (13F)

As of Jun 30, 2026 (Q2 2026), 149 institutions reported holding 364,595,242 LXRX shares, valued at $875.0M as reported, 85.7% of its market cap (market cap of Jun 26, 2026). That is +13 institutions from the quarter before. Among managers whose reports for both quarters are comparable, 44 opened a position, 30 closed one, 36 added and 36 trimmed.

Top Holders, Q2 2026

ManagerSharesValueChange
Artal Group S.A.175,156,062$420.4M+20,421,735
FMR LLC51,782,045$124.3M+6,725,707
Siren, L.L.C.44,303,518$106.3MUnchanged
Sessa Capital IM, L.P.18,960,836$45.5M+1,047,875
BlackRock, Inc.17,348,741$41.6M+14,026,522
VANGUARD CAPITAL MANAGEMENT LLC9,901,208$23.8M+382,041
Point72 Asset Management, L.P.8,251,325$19.8M+436,719
GEODE CAPITAL MANAGEMENT, LLC6,244,372$15.0M+3,075,261
STATE STREET CORP4,917,769$11.8M+3,953,731
VANGUARD PORTFOLIO MANAGEMENT LLC2,357,749$5.7M+1,811,149

By Quarter

QuarterInstitutionsSharesValue
Q2 2026149364,595,242$875.0M
Q1 2026136323,381,236$504.5M
Q4 2025125260,427,476$299.5M
Q3 2025123255,170,139$344.5M
Q2 2025123257,126,468$243.7M
Q1 2025127265,835,250$122.5M
Q4 2024126297,662,526$220.1M
Q3 2024137288,707,465$453.2M
Q2 2024127281,716,974$475.6M

From the SEC's Form 13F data sets: investment managers with $100 million or more in Section 13(f) securities report their holdings each quarter, up to 45 days after it ends; a restated filing replaces the original, and values are as the managers reported them (a position whose price runs about 1,000 times below other managers', from a manager whose positions mostly do, is read as reported in thousands of dollars). The same shares can be reported by more than one manager, so totals can count some twice.

ETFs Holding LXRX

FundWeight of LXRXShares (as reported)Value (as reported)Source updated
IWM iShares Russell 2000 ETF0.01%5,995,463$10.6MOct 8, 2026
IWO iShares Russell 2000 Growth ETF0.03%2,134,854$3.8MOct 8, 2026
XPH State Street SPDR S&P Pharmaceuticals ETF0.79%2,052,156$3.7MOct 8, 2026
SCHA Schwab U.S. Small-Cap ETF0.01%1,114,293$1.9MOct 8, 2026
IWC iShares Micro-Cap ETF0.09%710,962$1.3MOct 8, 2026
PRFZ Invesco RAFI US 1500 Small-Mid ETF0.02%254,467$447.9KOct 8, 2026
BBC Virtus Biotech Clinical Trials ETF0.71%165,278$290.9KOct 8, 2026
GSSC Goldman Sachs ActiveBeta U.S. Small Cap Equity ETF0.03%164,925$288.6KOct 8, 2026
SCHB Schwab U.S. Broad Market ETF0.00%111,912$195.5KOct 8, 2026
RSSL Global X - Russell 2000 ETF0.01%107,835$188.7KOct 7, 2026
FHLC Fidelity MSCI Health Care Index ETF0.01%106,563$187.6KOct 8, 2026
IWV iShares Russell 3000 ETF0.00%85,298$150.1KOct 8, 2026
PILL Direxion Daily Pharmaceutical & Medical Bull 3X ETF0.18%53,575$94.3KOct 8, 2026
QQQS Invesco NASDAQ Future Gen 200 ETF0.41%53,319$93.8KOct 8, 2026
WSML iShares MSCI World Small-Cap ETF0.00%18,179$32.0KOct 8, 2026

From each fund's latest holdings file on record that shows LXRX's listed security itself. A file counts when its line count is consistent with the fund's reported holdings count (at most twice it plus 10, or at most 1,000 lines for a reported count of exactly 10, which the data source gives many funds as a cap), read with that file or inherited from the fund's last classified file (within 20% of its line count, read within 60 days). Funds whose line for the company could not be confirmed as LXRX's listed security, or that hold it through underlying funds (look-through), are not listed. Only long positions count: a fund is left out when any of its lines for LXRX reports a negative weight, share count or value, or none of them above zero (a short position, or figures that disagree). Shares, value and weight are as reported in each fund's file, dated by the data source's last update of that file (not the date of the positions); the weight is LXRX's share of that fund.

How to Read LXRX Insider Activity

Net insider sentiment is bullish over the trailing twelve months: 8 buy transactions versus 0 sales. Cluster buying by officers or directors is one of the cleaner insider signals because purchases require personal capital deployment and carry direct SEC scrutiny for material non-public information violations. The transaction table above includes the filer's reporting name, transaction type, share count, per-share price, and total dollar value where computable. For options traders, insider activity is one input to event-driven sizing alongside earnings calendar, analyst-rating cluster moves, and the implied-vol surface. Form 4 filings (the dominant Section 16 reporting form) must be submitted within two business days of the transaction; clusters of buys across multiple insiders within a short window are the strongest informational pattern. SEC EDGAR carries the underlying source filings for verification and additional historical depth.

Learn how insider trading is reported and how to read the data →

Frequently asked LXRX insider trading questions

How active are LXRX insiders right now?
Over the trailing twelve months, Lexicon Pharmaceuticals, Inc. (LXRX) insiders made 8 buy transactions and 0 sale transactions. Net insider sentiment over the trailing twelve months tilts to the buy side (8 buys vs 0 sales). The transaction list above shows the most recent filings; each entry includes the insider's name, transaction type, share count, and per-share price.
What counts as an insider transaction?
Section 16 of the Securities Exchange Act requires officers, directors, and 10% beneficial-owner shareholders to disclose changes in their holdings via Form 3 (initial statement), Form 4 (subsequent transactions, filed within two business days), and Form 5 (annual catch-up). Insider transactions cover open-market purchases and sales, exercise of stock options, gifts, and grants. The "transaction type" field on each row distinguishes these subcategories.
Are LXRX insider buys a bullish signal?
Insider purchases (Type P, made on the open market or privately; the code covers both) carry more informational weight than insider sales: an insider must commit personal capital, and the SEC scrutinizes purchases under Rule 10b5-1 for material non-public information. Sales, by contrast, are often driven by liquidity, tax planning, or pre-scheduled 10b5-1 trading plans rather than negative information. Cluster buying (multiple insiders buying within a short window) is a stronger signal than isolated buys.
How do LXRX insider transactions affect options pricing?
Insider transaction data does not directly drive implied volatility, but Form 4 disclosures can move single-name IV if the size or timing is unusual (e.g. a large CEO buy ahead of an earnings window). Options markets price the marginal informational content; routine transactions under pre-scheduled plans are typically ignored. For event-driven options sizing, pair the insider transaction history with the upcoming earnings calendar.