Denali Therapeutics Inc. (DNLI) IV/HV History

Comparing implied volatility to historical (realized) volatility reveals whether options are priced rich or cheap relative to actual price movement. Persistent gaps can signal trading opportunities.

Denali Therapeutics Inc. (DNLI) operates in the Healthcare sector, specifically the Biotechnology industry, with a market capitalization near $3.14B, listed on NASDAQ, employing roughly 443 people, carrying a beta of 0.99 to the broader market. Denali Therapeutics Inc. Led by Ryan J. Watts, public since 2017-12-08.

Snapshot as of May 15, 2026.

Spot Price
$18.72
ATM IV
67.6%
HV 20-Day
48.8%
HV 60-Day
61.3%
IV Rank
12.2%
IV Percentile
27.4%

As of May 15, 2026, Denali Therapeutics Inc. (DNLI) ATM implied volatility is 67.6%. 20-day realized volatility is 48.8%, producing an IV-HV spread of +18.8 vol points. Options are pricing in more volatility than the stock has recently delivered, the volatility risk premium. IV rank is 12.2%.

How DNLI iv/hv history Data Feeds Strategy Selection

Strategy selection on Denali Therapeutics Inc. options does not derive from any single metric in isolation. The iv/hv history view above sits inside a broader read: ATM IV currently sits at 67.6% and dealer gamma exposure is positive, so dealer hedging is mechanically mean-reverting. Combine the iv/hv history data here with the volatility-skew surface, dealer-gamma exposure, max-pain level, and upcoming-events calendar to build a positioning thesis. Risk-defined structures (credit spreads, debit spreads, iron condors) are usually safer than naked positions while the regime is uncertain; the data on this page anchors the inputs but does not by itself constitute a trade thesis.

Learn how implied vs realized volatility is reported and how to read the data →

Frequently asked DNLI iv/hv history questions

Is DNLI options pricing rich or cheap right now?
As of May 15, 2026, Denali Therapeutics Inc. (DNLI) ATM IV is 67.6% against 20-day realized volatility of 48.8%. IV rank is 12.2%. DNLI options are pricing in more volatility than the stock has recently realized: a positive variance risk premium worth 18.8 vol points.
What is the DNLI variance risk premium?
The variance risk premium is the persistent gap between implied and subsequently realized volatility. In equity markets it averages positive because option sellers demand compensation for bearing variance shocks. DNLI is currently priced consistently with this premium, which is one input to whether short-vol or long-vol structures carry their typical edge.
What does DNLI IV rank mean for strategy selection?
IV rank normalizes the current ATM IV to its 1-year range: 0% is the low, 100% is the high. DNLI's current rank of 12.2% signals where current pricing sits in its own 1-year history. High-rank regimes typically favor premium-selling structures (credit spreads, condors, covered calls); low-rank regimes typically favor premium-buying or long-volatility structures.